| Title: | The 'cognitive footprint' of psychiatric and neurological conditions: cross-sectional study in the UK Biobank cohort |
| Journal: | Acta Psychiatrica Scandinavica |
| Published: | 7 Apr 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28387438/ |
| DOI: | https://doi.org/10.1111/acps.12733 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acps.12733 |
Publication 793
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Abstract
OBJECTIVE: We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson's disease, within a large general population cohort.</p>
METHOD: Cross-sectional study using UK Biobank data (n = 502 642). Psychiatric and neurological exposure status was ascertained via self-reported diagnoses, hospital records and questionnaires. Impairment on reasoning, reaction time and memory tests was defined with reference to a single unexposed comparison group. Results were standardised for age and gender. Sensitivity analyses examined the influence of comorbidity, education, information sources and missing data.</p>
RESULTS: Relative to the unexposed group, cognitive impairment was least common in major depression (standardised prevalence ratios across tests = 1.00 [95% CI 0.98, 1.02] to 1.49 [95% CI 1.24, 1.79]) and most common in schizophrenia (1.89 [95% CI 1.47, 2.42] to 3.92 [95% CI 2.34, 6.57]). Prevalence in mania/bipolar was similar to that in multiple sclerosis and Parkinson's disease. Estimated population attributable prevalence of cognitive impairment was higher for major depression (256 per 100 000 [95% CI 130, 381]) than for all other disorders.</p>
CONCLUSION: Although the relative prevalence of cognitive impairment was lowest in major depression, the population attributable prevalence was highest overall for this group.</p>
5 Authors
- B. Cullen
- D. J. Smith
- I. J. Deary
- J. J. Evans
- J. P. Pell
1 Application
| Application ID | Title |
|---|---|
| 11332 | Cognitive outcomes in people with behavioural and brain disorders within UK Biobank |
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