Contact for queries: Alistair.Young@kcl.ac.uk or firstname.lastname@example.org
This returned dataset contains CMR data on the first ~5000 participants who attended the imaging enhancement visit.
This category contains derived data from cardiovascular magnetic resonance (CMR) short-axis tagged images acquired in the basal, mid and apical levels of the left ventricle. Myocardial strain measurements were calculated via semi-automated analyses using CIMTag2D software (CIMTag2D v.8.1.5, Auckland MRI Research Group, New Zealand). Manual adjustments of the tagging grid were made in the end-diastolic (first frame), end-systolic (manually defined at the mid slice), early diastolic phase (rapid filling phase) and also in the last frame.
Returned data contains:
1) Image derived phenotypes:
- End-systolic circumferential strain (apex)
- End-systolic circumferential strain (base)
- End-systolic circumferential strain (mid)
- End-systolic torsion
- End-systolic torsion rate
2) Quality control scores of CMR tagging images and analysis
Description of cardiovascular phenotype in the UK Biobank population based on cardiovascular magnetic resonance and carotid ultrasound
Imaging of the heart and blood vessels is performed in a large subset of the UK Biobank cohort. Many measures defining the state of the heart and blood vessels can be derived from the images acquired. These measures are influenced by various health conditions and modifiable and non-modifiable factors, such as age, gender and ethnicity. The aim of this proposal is to describe the measures of the heart and blood vessel in the UK Biobank population and investigate how much modifiable and non-modifiable factors influence them. All new data will be made available for future research. Knowing the reference ranges for common imaging measures of the heart and circulation and how they are influenced by factors, such as age, gender, ethnicity, risk factors for heart attacks and strokes, is key for improving making diagnoses and predicting health outcomes. Descriptive statistics will be performed for all image derived phenotypes (IDPs) from the cardiovascular magnetic resonance (CMR) and carotid ultrasound images. We will perform subgroup analysis for important clinical factors, such as age, gender, cardiovascular risk, chronic conditions (e.g. Diabetes). We will apply descriptive statistics to a subpopulation considered `healthy without cardiovascular disease or presence of modifiable risk factors`. Univariate and multivariate regression analysis will be used to assess relationships between IDPs and relevant co-variates. We will also assess intra- and inter-observer variability for IDP measurement when repeat analysis is available. Initial 5000 subjects from the imaging enhancement study.
|Lead investigator:||Professor Steffen Petersen|
|Lead institution:||Queen Mary University of London|