| Application: | 3593, Osteoporosis, fractures and cardiovascular risk |
| Title: | COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants |
| Size: | 593281 B |
| Archived: | 17 Nov 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 2827
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Notes
Frailty and multimorbidity have been suggested as risk factors for severe COVID-19 disease. We therefore investigated whether frailty and multimorbidity were associated with risk of hospitalisation with COVID-19 in the UK Biobank, utilising a modified assessment of frailty from baseline data, based on Fried s classification. At the time of writing, COVID-19 test results were available 16/03/2020-01/06/2020 and mostly taken in hospital settings. Compared to the non-tested group, after adjustment, COVID-19 positive participants were more likely to be frail, report slow walking speed and be have four or more comorbidities. However, similar strength of associations were apparent when comparing COVID-19 negative and non-tested groups. Furthermore, frailty and multimorbidity were not associated with COVID-19 diagnoses, when comparing COVID-19 positive and COVID-19 negative participants. We surmised that frailty and multimorbidity do not appear to aid risk stratification, in terms of a positive versus negative results of COVID-19 testing. We intend to further investigate the prognostic value of these markers for adverse clinical sequelae following COVID-19 disease within the UK Biobank, as further data is made available.Application 3593
Osteoporosis, fractures and cardiovascular risk
Osteoporosis (thinning of the bones), and ischaemic heart disease (narrowing of arteries in the heart) are both common conditions associated with an enormous burden of ill health and decreased survival across the population. Recent studies have suggested that people who have osteoporosis are more likely to have narrowing of their arteries and are also likely to die earlier than those who do not. However such studies have usually been small and unable to investigate potential underlying mechanisms. We will use the whole UK Biobank cohort to initially explore the relationships between baseline measures of bone density (heel ultrasound), and risk factors for heart attacks and strokes such as blood pressure, pulse wave velocity and aortic stiffness and pre-existing heart disease, whilst controlling for other factors such as coexisting disease, medications, lifestyle, physical activity and family history. We will then investigate, when the assay results become available, whether these relationships are mediated via markers of chronic inflammation and other factors such as vitamin D and sex-hormone levels. We will also request data on new cardiovascular events such that after 5 years, longitudinal associations can be explored.
| Lead investigator: | Professor Nicholas Harvey |
| Lead institution: | University of Southampton |
1 related Return
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 1472 | 3593 | Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: Findings from the UK Biobank Cohort | 5 Jul 2018 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2828 | COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants | Woolford SJ et al. | 2020 | Aging Clin Exp Res |
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