| Title: | COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants |
| Journal: | Aging Clin Exp Res |
| Published: | 1 Sep 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32705587/ |
| DOI: | https://doi.org/10.1007/s40520-020-01653-6 |
Publication 2828
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Abstract
Frailty and multimorbidity have been suggested as risk factors for severe COVID-19 disease. We therefore investigated whether frailty and multimorbidity were associated with risk of hospitalisation with COVID-19 in the UK Biobank, utilising a modified assessment of frailty from baseline data, based on Fried s classification. At the time of writing, COVID-19 test results were available 16/03/2020-01/06/2020 and mostly taken in hospital settings. Compared to the non-tested group, after adjustment, COVID-19 positive participants were more likely to be frail, report slow walking speed and be have four or more comorbidities. However, similar strength of associations were apparent when comparing COVID-19 negative and non-tested groups. Furthermore, frailty and multimorbidity were not associated with COVID-19 diagnoses, when comparing COVID-19 positive and COVID-19 negative participants. We surmised that frailty and multimorbidity do not appear to aid risk stratification, in terms of a positive versus negative results of COVID-19 testing. We intend to further investigate the prognostic value of these markers for adverse clinical sequelae following COVID-19 disease within the UK Biobank, as further data is made available.1 Author
- Woolford SJ et al.
1 Application
| Application ID | Title |
|---|---|
| 3593 | Osteoporosis, fractures and cardiovascular risk |
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