| Application: | 41245, Importance of healthy lifestyle on chronic neurological conditions |
| Title: | Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank |
| Size: | 645 B |
| Archived: | 15 Sep 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3822
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Notes
BackgroundMultiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored.
Objective
To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS).
Methods
By using a case control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30 kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95% confidence intervals (CIs).
Results
728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0 1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71% lower odds of having MS (OR = 0.29; 95% CI: 0.15 0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS.
Conclusion
Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.
Application 41245
Importance of healthy lifestyle on chronic neurological conditions
The aim of this project is to investigate how lifestyle (in particular diet and physical activity) is associated with the most common neurological diseases. In addition, we will explore how these lifestyle behaviors are associated with outcomes such as cognitive function (e.g. memory, attention) and brain structures, in a range of neurological diseases. We plan on undertaking this research to understand if healthy lifestyle (dietary patterns and physical activity) may be related to the prevention of neurological and management of diseases. As for dietary patterns, we will consider some patterns traditionally associated with lower (e.g. Mediterranean diet) or higher (e.g. dietary inflammatory index) risk of common diseases and unwanted outcomes. We will do the same for physical activity level (assessed through self-reported and devices which measure this objectively ) in order to see if higher physical activity level is associated with a lower risk of neurological conditions. Finally, we will explore the association between diet and physical activity with cognition, since dementia and cognitive issues are unfortunately common in people having all kinds of neurological conditions. In this regard, we will explore the factors that can explain any relationships that we observe. We will undertake this research using anonymous data. The project will last 36 months and we will publish several papers regarding, present our findings at conferences and provide lay summaries for patients. We believe that our data can be of high public health importance, since neurological diseases are very common and usually associated with a high rate of disability and low quality of life. To understand if diet and physical activity are associated with a lower risk of these conditions and to a better cognitive status is very important, in order to suggest these interventions as prevention for neurological conditions.
| Lead investigator: | Dr Nicola Veronese |
| Lead institution: | IRCCS De Bellis |
1 related Return
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3823 | 41245 | Neurological diseases and COVID-19: prospective analyses using the UK Biobank | 15 Sep 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3823 | Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank | Nicola Veronese (+12) | 2020 | Nutritional Neuroscience |
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