| Title: | Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank |
| Journal: | Nutr Neurosci |
| Published: | 9 Dec 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33297884/ |
| DOI: | https://doi.org/10.1080/1028415X.2020.1846357 |
Publication 3823
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Abstract
BackgroundMultiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored.
Objective
To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS).
Methods
By using a case control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30 kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95% confidence intervals (CIs).
Results
728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0 1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71% lower odds of having MS (OR = 0.29; 95% CI: 0.15 0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS.
Conclusion
Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.
1 Author
- Veronese N et al.
1 Application
| Application ID | Title |
|---|---|
| 41245 | Importance of healthy lifestyle on chronic neurological conditions |
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