| Title: | Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk |
| Journal: | European Heart Journal |
| Published: | 5 Dec 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34891159/ |
| DOI: | https://doi.org/10.1093/eurheartj/ehab809 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614342 |
| Citations: | 45 (37 in last 2 years) as of 8 Aug 2024 |
Publication 12379
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Abstract
AIMS: Low vitamin D status is associated with a higher risk for cardiovascular diseases (CVDs). Although most existing linear Mendelian randomization (MR) studies reported a null effect of vitamin D on CVD risk, a non-linear effect cannot be excluded. Our aim was to apply the non-linear MR design to investigate the association of serum 25-hydroxyvitamin D [25(OH)D] concentration with CVD risk.</p>
METHODS AND RESULTS: The non-linear MR analysis was conducted in the UK Biobank with 44 519 CVD cases and 251 269 controls. Blood pressure (BP) and cardiac-imaging-derived phenotypes were included as secondary outcomes. Serum 25(OH)D concentration was instrumented using 35 confirmed genome-wide significant variants.We also estimated the potential reduction in CVD incidence attributable to correction of low vitamin D status. There was a L-shaped association between genetically predicted serum 25(OH)D and CVD risk (Pnon-linear = 0.007), where CVD risk initially decreased steeply with increasing concentrations and levelled off at around 50 nmol/L. A similar association was seen for systolic (Pnon-linear = 0.03) and diastolic (Pnon-linear = 0.07) BP. No evidence of association was seen for cardiac-imaging phenotypes (P = 0.05 for all). Correction of serum 25(OH)D level below 50 nmol/L was predicted to result in a 4.4% reduction in CVD incidence (95% confidence interval: 1.8- 7.3%).</p>
CONCLUSION: Vitamin D deficiency can increase the risk of CVD. Burden of CVD could be reduced by population-wide correction of low vitamin D status.</p>
8 Keywords
- Cardiovascular Diseases
- Humans
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Risk Factors
- Vitamin D
- Vitamin D Deficiency
- Vitamins
3 Authors
- Ang Zhou
- Joseph B Selvanayagam
- Elina Hyppönen
1 Application
| Application ID | Title |
|---|---|
| 20175 | Nutrition, diet and health: examining causal associations and gene-environment interactions |
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