| Title: | Differences in cardiovascular outcomes between men and women with acute pancreatitis. |
| Journal: | Polish Archives of Internal Medicine |
| Published: | 30 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39475464/ |
| DOI: | https://doi.org/10.20452/pamw.16867 |
Publication 13661
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Abstract
INTRODUCTION: The risk of cardiovascular disease increases in patients with acute pancreatitis (AP). However, it remains unknown whether this increase varies between sexes.</p>
OBJECTIVES: Our aim was to assess sex differences in cardiovascular outcomes in AP patients during long-term follow-up.</p>
PATIENTS AND METHODS: The participants were recruited from the United Kingdom Biobank, which is a population-based cohort study consisting of 502 368 individuals aged 40-69 years old. Cardiovascular outcomes were defined as major cardiovascular and cerebrovascular adverse events (MACCEs), encompassing all-cause death, myocardial infarction, and stroke. We compared sex difference in MACCE incidence using incidence rate per 1000 person-years. The association between sex and MACCE risk was assessed using the Cox proportional hazards models and win ratio method, adjusted for demographic, lifestyle, metabolic factors, and medication use.</p>
RESULTS: A total of 1371 participants with AP were included, 42.5% were men. Over the median (interquartile range) follow-up of 13.9 (13-14.7) years, 226 MACCEs occurred. The incidence rate of MACCE was 16.44 for men and 9.8 for women. The multivariate Cox regression analysis indicated a higher risk of MACCEs in men than in women (hazard ratio [HR], 1.8; 95% CI, 1.36-2.38). Adjusted HR for all-cause mortality, myocardial infarction, and stroke were 1.49, 2.75, and 1.67, respectively. The adjusted win ratio by inverse probability of treatment weighting was 0.55 (P <0.001), suggesting a worse outcome in men.</p>
CONCLUSIONS: Men experienced more adverse cardiovascular outcomes than women in long follow-up after AP, suggesting a need for sex-specific management strategies in AP patients.</p>
15 Keywords
- Adult
- Aged
- Cardiovascular Diseases
- Cohort Studies
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Myocardial Infarction
- Pancreatitis
- Proportional Hazards Models
- Risk Factors
- Sex Factors
- United Kingdom
12 Authors
- Manyun Tang
- Yuye Ning
- Jiaqi An
- Bohan Li
- Changying Zhao
- Lin Ting
- Kai Qu
- Gary Tse
- Jeffrey Shi Kai Chan
- Duolao Wang
- Chang Liu
- Guoliang Li
1 Application
| Application ID | Title |
|---|---|
| 152047 | Investigation of Genetic, Lifestyle, Environmental, and Clinical Determinants on Non-Communicable Diseases (NCDs) and Infectious Diseases, and their Interactions. |
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