| Title: | Accelerometer-measured physical activity timing with incident dementia |
| Journal: | Alzheimer's & Dementia |
| Published: | 27 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39868637/ |
| DOI: | https://doi.org/10.1002/alz.14452 |
Publication 14967
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Abstract
INTRODUCTION: Moderate to vigorous physical activity (MVPA) is linked to lower dementia risk, though the optimal timing remains unclear.</p>
METHODS: Using accelerometer-measured MVPA data from 90,329 dementia-free UK Biobank participants with at least 2 years of follow-up, we assessed associations between MVPA patterns (morning, afternoon, evening, mixed, inactive) and dementia risk via multivariable-adjusted Cox proportional hazards models.</p>
RESULTS: Compared to the inactive group, participants with a tendency of morning MVPA had a lower risk of all-cause dementia (hazard ratio [HR]: 0.60, 95% confidence interval [CI]: 0.40-0.90) and Alzheimer's disease (AD) risk (HR: 0.44, 95% CI: 0.22-0.86). No association of the other time point with all-cause dementia was observed. Additionally, the incidence of vascular dementia (VD) did not exhibit a significant relationship among all timing groups.</p>
DISCUSSION: Morning MVPA was associated with a lower risk of all-cause dementia and AD, while MVPA at any time point showed no association with VD.</p>
HIGHLIGHTS: Few studies have examined accelerometer-measured moderate to vigorous physical activity (MVPA) timing with incident dementia. Participants with a tendency of morning MVPA had a lower risk of all-cause dementia and Alzheimer's disease. No significant association was found between all MVPA timing and vascular dementia (VD) risk. Findings suggest timing-specific physical activity interventions for dementia prevention.</p>
14 Keywords
- Accelerometry
- Aged
- Alzheimer Disease
- Dementia
- Exercise
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Proportional Hazards Models
- Risk Factors
- Time Factors
- United Kingdom
4 Authors
- Yuye Ning
- Meilin Chen
- Hao Yang
- Jianping Jia
1 Application
| Application ID | Title |
|---|---|
| 150493 | Influence of Lifestyle, Environmental Factors, and Genetic Drive on Neurodegenerative Pathogenesis and Brain Health |
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