| Title: | Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour |
| Journal: | Nature Communications |
| Published: | 5 Apr 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30952852/ |
| DOI: | https://doi.org/10.1038/s41467-019-09576-1 |
| URL: | https://www.nature.com/articles/s41467-019-09576-1.pdf |
Publication 8826
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Abstract
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10−8, of which 20 reach a stricter threshold of P < 8 × 10−10. These include 26 novel associations with measures of sleep quality and 10 with nocturnal sleep duration. The majority of identified variants associate with a single sleep trait, except for variants previously associated with restless legs syndrome. For sleep duration we identify a missense variant (p.Tyr727Cys) in PDE11A as the likely causal variant. As a group, sleep quality loci are enriched for serotonin processing genes. Although accelerometer-derived measures of sleep are imperfect and may be affected by restless legs syndrome, these findings provide new biological insights into sleep compared to previous efforts based on self-report sleep measures.</p>
32 Authors
- Samuel E. Jones
- Vincent T. van Hees
- Diego R. Mazzotti
- Pedro Marques-Vidal
- Séverine Sabia
- Ashley van der Spek
- Hassan S. Dashti
- Jorgen Engmann
- Desana Kocevska
- Jessica Tyrrell
- Robin N. Beaumont
- Melvyn Hillsdon
- Katherine S. Ruth
- Marcus A. Tuke
- Hanieh Yaghootkar
- Seth A. Sharp
- Yingjie Ji
- Jamie W. Harrison
- Rachel M. Freathy
- Anna Murray
- Annemarie I. Luik
- Najaf Amin
- Jacqueline M. Lane
- Richa Saxena
- Martin K. Rutter
- Henning Tiemeier
- Zoltán Kutalik
- Meena Kumari
- Timothy M. Frayling
- Michael N. Weedon
- Philip R. Gehrman
- Andrew R. Wood
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