Summary: In this cross-sectional analysis of the UK Biobank cohort, a history of fracture was associated with increased risk of current widespread chronic pain. Purpose/Introduction: We aimed to test the hypothesis that a history of fracture is associated with reporting chronic widespread bodily pain (CWBP), using baseline data from the UK Biobank cohort, comprising 502,656 people aged 40 69 years.
Methods: The case definition of current chronic widespread bodily pain was based on a response of yes to the question do you have pain all over the body? and yes to and have you experienced pain all over the body for more than 3 months? Multivariable Poisson regression with robust standard errors was used to test the relationship between fracture (occurring within 5 years prior to the baseline interview, and recorded by self-report) at the spine, hip, upper limb or lower limb and CWBP, adjusting for confounders.
Results: Of 501,733 participants (mean age 56.5 years), 7130 individuals reported CWBP and 23,177 had a history of fracture affecting the upper limb, lower limb, spine and/or hip. Individuals with prior fracture were significantly more likely to report CWBP than those without. After adjustment for potential risk factors (age, gender, demographic, lifestyle and socioeconomic, and psychological), risk ratios were attenuated but remained statistically significant with a more than doubling of risk for CWBP with spine fractures in men (risk ratio (RR) 2.67, 95 % confidence interval (CI) 1.66 4.31; p?<?0.001) and women (RR 2.13, 95 % CI 1.35 3.37, p?=?0.001) and with hip fractures in women (RR 2.19, 95 % CI 1.33 3.59; p?=?0.002).
Conclusions: In this cross-sectional analysis, previous fracture is associated with an increased likelihood of chronic widespread bodily pain, particularly with hip fractures in women, and spine fractures in both sexes. If replicated, these findings may help inform the identification of those most at risk of chronic widespread pain post-fracture, allowing preventative measures to be targeted.
Walker-Bone, K., Harvey, N.C., Ntani, G. et al. Chronic widespread bodily pain is increased among individuals with history of fracture: findings from UK Biobank Arch Osteoporos (2016) 11: 1. doi:10.1007/s11657-015-0252-1
Epidemiology of chronic pain
This project will investigate the epidemiology of chronic pain. It will determine:
* how common pain is at individual sites throughout the body as well as `widespread body pain`
*the factors associated with the reporting of pain including demographic (age, sex, socioeconomic status), lifestyle factors (smoking , alcohol, physical activity)
*other health related factors reported with pain (e.g. fatigue and mood disorders)
*whether persons who report pain also report markers of poor cardiovascular (heart) and respiratory (lung) health and whether their lifestyle puts them at an increased risk of cancer.
*the relationship between reporting of pain and history of falls and fractures.
The project meets Biobank's purpose by researching common and disabling symptoms in the population with a view to further understanding their aetiology. Such knowledge will help to inform the design of future trials to optimise management.
This application requires only data on the full cohort. project It requires linkage to cancer incidence and mortality data (as and when it becomes available), and requires baseline data on lifestyle and psychosocial factors, medical conditions, bone densitometry and blood pressure;
|Lead investigator:||Professor Gary Macfarlane|
|Lead institution:||University of Aberdeen|
4 related Returns
|Return ID||App ID||Description||Archive Date|
|2764||1144||Is alcohol consumption related to likelihood of reporting chronic widespread pain in people with stable consumption? Results from UK biobank||3 Nov 2020|
|2766||1144||Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis||3 Nov 2020|
|1541||1144||Self-Reported Facial Pain in UK Biobank Study: Prevalence and Associated Factors||10 Aug 2018|
|3417||1144||The epidemiology of regular opioid use and its association with mortality: Prospective cohort study of 466 486 UK biobank participants||18 May 2021|