| Application: | 7155, Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
| Title: | Chronic multisite pain in major depression and bipolar disorder: cross-sectional study of 149, 611 participants in UK Biobank |
| Size: | 324260 B |
| Archived: | 5 Jul 2018 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 1476
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Notes
There is a lack of research into links between chronic, multisite pain, and mood disorder. We looked at around 150 thousand participants with relevant data. We found that people with bipolar disorder and major depressive disorder had around 5% increased prevalence of multisite pain across the body. This suggests that people who report chronic pain and pain in multiple sites, are at higher risk for bipolar disorder.Application 7155
Epidemiology of mental health, cognitive function, pain and cardiometabolic disease.
Mental health problems place a large burden on the health service. As life expectancy increases, understanding cognitive decline is increasingly important. Identifying high risk groups enables us to detect problems early and target resources. Understanding the distribution of disease between groups can help elucidate the causes of disease and help identify new methods of prevention and treatment. Aim: To study the epidemiology of mental health, cognitive function, pain and cardiometabolic disease. Objectives: To examine the frequency, distribution, determinants and outcomes of these conditions, in relation to: demographics, lifestyle, comorbidity and medication UKB is representative of the general population in terms of age, sex and ethnicity but unrepresentative in terms of lifestyle. Therefore, it is not suitable to determine the overall prevalence of any condition but can, nonetheless, be used to compare the distribution of diseases between sub-groups and therefore determine associations between risk factors and disease frequency and outcome. This project builds on our ongoing study (774) which examines ethnic differences in cardiometabolic disease. We seek to extend the focus to examine other determinants of cardiometabolic disease as well as determinants of mood disorder, cognitive impairment and pain. We will compare participants with and without mood disorder, pain, cognitive impairment and cardiometabolic diease and participants with varying severity of these conditions in relation to a series of demographic and lifestyle factors in order to determine the factors associated with the conditions. We will also examine the association between these conditions and other diseases. The findings will help to identify individual at increased risk and modifiable factors that may help to prevent or alleviate these conditions. all participants
| Lead investigator: | Professor Jill Pell |
| Lead institution: | University of Glasgow |
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1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 1477 | Chronic multisite pain in major depression and bipolar disorder: cross-sectional study of 149,611 participants in UK Biobank | Barbara I Nicholl (+12) | 2014 | BMC Psychiatry |
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