Background: Low birth weight has been inconsistently associated with risk of developing affective disorders, including major depressive disorder (MDD). To date, studies investigating possible associations between birth weight and bipolar disorder (BD), or personality traits known to predispose to affective disorders such as neuroticism, have not been conducted in large cohorts. Aims:To assess whether very low birth weight (<1500 g) and low birth weight (1500 2490 g) were associated with higher neuroticism scores assessed in middle age, and lifetime history of either MDD or BD. We controlled for possible confounding factors.
Method: Retrospective cohort study using baseline data on the 83 545 UK Biobank participants with detailed mental health and birth weight data. Main outcomes were prevalent MDD and BD, and neuroticism assessed using the Eysenck Personality Inventory Neuroticism scale - Revised (EPIN-R)
Results: Referent to normal birth weight, very low/low birth weight were associated with higher neuroticism scores, increased MDD and BD. The associations between birth weight category and MDD were partially mediated by higher neuroticism.
Conclusions: These findings suggest that intrauterine programming may play a role in lifetime vulnerability to affective disorders.
Lyall DM, Inskip HM, Mackay D, Deary IJ, McIntosh AM, Hotopf M, Kendrick T, Pell JP, Smith DJ (2016) Low birth weight and features of neuroticism and mood disorder in 83?545 participants of the UK Biobank cohort, British Journal of Psychiatry Open Jan 2016, 2 (1) 38-44; DOI: 10.1192/bjpo.bp.115.002154
Cross-sectional study to investigate ethnic differences in cardiovascular risk and mental health
One advantage of UK Biobank is the recruitment of participants from ethnic minority groups in sufficient numbers to enable meaningful comparisons of different ethnic groups. Ethnic groups are known to differ in their risk of a number of conditions including cardiovascular disease and mental health. For example Pakistani people have a high risk of heart disease and chinese people a high risk of high blood pressure and stroke. Understanding these differences and the reasons for them is of assistance in ensuring the appropriateness and effectiveness of screening, investigation and treatment interventions.
The aim of this study is to compare the different ethnic minority groups in terms of the amount and type of disease, the distribution by age, sex and socioeconomic deprivation and the lifestyle and environmental factors that are associated with the presence of disease.
In this study we will access only questionnaire and measurement data and compare ethnic sub-groups in terms of these data. At a later date, once available, we will be able to compare these sub-groups in terms of their biochemistry assays and follow-up events. Therefore, this initial study will focus on comparisons of risk and only later will we be able to make comparisons of actual disease occurrence.
|Lead investigator:||Professor Jill Pell|
|Lead institution:||University of Glasgow|
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|505||Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort||Lyall DM et al.||2016||BJPsych Open|