Aims: Cardiometabolic diseases (hypertension, coronary artery disease [CAD] and diabetes are known to associate with poorer cognitive ability but there are limited data on whether having more than one of these conditions is associated with additive effects. We aimed to quantify the magnitude of their associations with non-demented cognitive abilities and determine the extent to which these associations were additive.
Methods and results: We examined cognitive test scores in domains of reasoning, information processing speed and memory, included as part of the baseline UK Biobank cohort assessment (N=474 129 with relevant data), adjusting for a range of potentially confounding variables. The presence of hypertension, CAD and diabetes generally associated with poorer cognitive scores on all tests, compared with a control group that reported none of these diseases. There was evidence of an additive deleterious dose effect of an increasing number of cardiometabolic diseases, for reasoning scores (unstandardized additive dose beta per disease=-0.052 score points out of 13, 95% CI [confidence intervals] -0.063 to-0.041, P<0.001), log reaction time scores (exponentiated beta=1.005, i.e. 0.5% slower, 95% CI 1.004 1.005, P<0.001) and log memory errors (exponentiated beta=1.005 i.e. 0.5% more errors; 95% CI 1.003 1.008).
Conclusion: Cardiometabolic diseases are associated with worse cognitive abilities, and the potential effect of an increasing number of cardiometabolic conditions appears additive. These results reinforce the notion that preventing or delaying cardiovascular disease or diabetes may delay cognitive decline and possible dementia.
Lyall DM, Celis-Morales CA, Anderson J, Gill JMR, Mackay DF, McIntosh AM, Smith DJ, Deary IJ, Sattar N, Pell JP (2017) Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants. Eur Heart J 2017; 38 (8): 577-583. doi: 10.1093/eurheartj/ehw528
Cross-sectional study to investigate ethnic differences in cardiovascular risk and mental health
One advantage of UK Biobank is the recruitment of participants from ethnic minority groups in sufficient numbers to enable meaningful comparisons of different ethnic groups. Ethnic groups are known to differ in their risk of a number of conditions including cardiovascular disease and mental health. For example Pakistani people have a high risk of heart disease and chinese people a high risk of high blood pressure and stroke. Understanding these differences and the reasons for them is of assistance in ensuring the appropriateness and effectiveness of screening, investigation and treatment interventions.
The aim of this study is to compare the different ethnic minority groups in terms of the amount and type of disease, the distribution by age, sex and socioeconomic deprivation and the lifestyle and environmental factors that are associated with the presence of disease.
In this study we will access only questionnaire and measurement data and compare ethnic sub-groups in terms of these data. At a later date, once available, we will be able to compare these sub-groups in terms of their biochemistry assays and follow-up events. Therefore, this initial study will focus on comparisons of risk and only later will we be able to make comparisons of actual disease occurrence.
|Lead investigator:||Professor Jill Pell|
|Lead institution:||University of Glasgow|
7 related Returns
|Return ID||App ID||Description||Archive Date|
|511||774||Adiposity among 132,479 UK Biobank participants; contribution of sugar intake vs other macronutrients||2 Jun 2017|
|513||774||Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants.||2 Jun 2017|
|501||774||Cognitive function and lifetime features of depression and bipolar disorder in a large population sample: Cross-sectional study of 143,828 UK Biobank participants||2 Jun 2017|
|463||774||Heaviness, health and happiness: a cross-sectional study of 163066 UK Biobank participants||23 May 2017|
|504||774||Low birth weight and features of neuroticism and mood disorder in 83545 participants of the UK Biobank cohort||2 Jun 2017|
|508||774||Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants.||2 Jun 2017|
|464||774||Psychiatry Gender differences in the association between adiposity and probable major depression: a cross-sectional study of 140,564 UK Biobank participants||23 May 2017|
|510||Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants.||Lyall et al||2017||Eur Heart J 2017|