Objectives: UK Biobank is a landmark cohort of over 500,000 participants which will be used to investigate genetic and nongenetic risk factors for a wide range of adverse health outcomes. This is the first study to systematically assess the prevalence and validity of proposed criteria for probable mood disorders within the cohort (major depression and bipolar disorder).
Methods: This was a descriptive epidemiological study of 172,751 individuals assessed for a lifetime history of mood disorder in relation to a range of demographic, social, lifestyle, personality and health-related factors. The main outcomes were prevalence of a probable lifetime (single) episode of major depression, probable recurrent major depressive disorder (moderate), probable recurrent major depressive disorder (severe), probable bipolar disorder and no history of mood disorder (comparison group). Outcomes were compared on age, gender, ethnicity, socioeconomic status, educational attainment, functioning, self-reported health status, current depressive symptoms, neuroticism score, smoking status and alcohol use.
Results: Prevalence rates for probable single lifetime episode of major depression (6.4%), probable recurrent major depression (moderate) (12.2%), probable recurrent major depression (severe) (7.2%) and probable bipolar disorder (1.3%) were comparable to those found in other population studies. The proposed diagnostic criteria have promising validity, with a gradient in evidence from no mood disorder through major depression and probable bipolar disorder in terms of gender distribution, socioeconomic status, self-reported health rating, current depressive symptoms and smoking.
Significance: The validity of our proposed criteria for probable major depression and probable bipolar disorder within this cohort are supported by these cross-sectional analyses. Our findings are likely to prove useful as a framework for a wide range of future genetic and non-genetic studies.
Smith DJ, Nicholl BI, Cullen B, Martin D, Ul-Haq Z, et al. (2013) Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants. PLoS ONE 8(11): e75362. doi:10.1371/journal.pone.0075362
Cross-sectional study to investigate ethnic differences in cardiovascular risk and mental health
One advantage of UK Biobank is the recruitment of participants from ethnic minority groups in sufficient numbers to enable meaningful comparisons of different ethnic groups. Ethnic groups are known to differ in their risk of a number of conditions including cardiovascular disease and mental health. For example Pakistani people have a high risk of heart disease and chinese people a high risk of high blood pressure and stroke. Understanding these differences and the reasons for them is of assistance in ensuring the appropriateness and effectiveness of screening, investigation and treatment interventions.
The aim of this study is to compare the different ethnic minority groups in terms of the amount and type of disease, the distribution by age, sex and socioeconomic deprivation and the lifestyle and environmental factors that are associated with the presence of disease.
In this study we will access only questionnaire and measurement data and compare ethnic sub-groups in terms of these data. At a later date, once available, we will be able to compare these sub-groups in terms of their biochemistry assays and follow-up events. Therefore, this initial study will focus on comparisons of risk and only later will we be able to make comparisons of actual disease occurrence.
|Lead investigator:||Professor Jill Pell|
|Lead institution:||University of Glasgow|
7 related Returns
|Return ID||App ID||Description||Archive Date|
|511||774||Adiposity among 132,479 UK Biobank participants; contribution of sugar intake vs other macronutrients||2 Jun 2017|
|509||774||Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants.||2 Jun 2017|
|513||774||Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants.||2 Jun 2017|
|501||774||Cognitive function and lifetime features of depression and bipolar disorder in a large population sample: Cross-sectional study of 143,828 UK Biobank participants||2 Jun 2017|
|463||774||Heaviness, health and happiness: a cross-sectional study of 163066 UK Biobank participants||23 May 2017|
|504||774||Low birth weight and features of neuroticism and mood disorder in 83545 participants of the UK Biobank cohort||2 Jun 2017|
|464||774||Psychiatry Gender differences in the association between adiposity and probable major depression: a cross-sectional study of 140,564 UK Biobank participants||23 May 2017|
|509||Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants.||Smith et al||2013||PLos ONE 2013|